Weight Loss Control By Altering Metabolism
Energy balance is responsible for controlling metabolism in healthy people, and it works through hormones in the blood. Research shows that insulin is responsible for storage of food within the cell as fat, and that leptin acts to suppress appetite to burn more energy. Bombesin is a recently discovered hormone, and it appears to be able to control appetite. All hormones works with cells through special areas called receptors.
Guam, Chen, et. al., writing in the journal Cell Metabolism, were interested in exploring the action of a specific bombesin receptor, called Bombesin Receptor Subtype-3 (BRS-3). In the design of their experiment, the researchers used two experimental chemicals on lab rats, attempting to effect the action of this cell area. If the results were promising, this research could be extended to development of a human medicine to control obesity.
Application of the first chemical caused the animals to consume more food. This particular chemical worked by stopping the action of this receptor, and the researchers shown that by so doing, the animals began to gain weight.
The second compound produced stunning results. Enhancing the action of bombesin at this receptor, the animals both ate less, and increased their metabolic rate – meaning that they reduced their appetite, and increased the amount of energy burned. An ideal situation for weight loss!
Additionally, the researchers reported that no side effects were seen during the course of this experiment. However, as it lasted only two weeks, more research needs to be performed. More exciting was the finding that the action of bombesin was not affected by other efforts to control metabolism. This hints at the possibility that a mixed medication could be developed and would work at multiple levels.
To be sure, a lot more study needs to be done to prove out that any developed medication is both safe and effective when it is ultimately sold. But, one can’t help but be excited that a drug to control obesity may soon become available.
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